Future research this website should explore mechanisms that underlie ethnic differences in the association between sleep and BMI.”
“The utilization of drug-eluting stents (DES) in “real world” practice has deviated from Food and Drug Administration-approved indications. Safety concerns have arisen from recent reports that suggested increased mortality and nonfatal myocardial infarction (MI) with DES usage. Little is known about the clinical outcomes of patients undergoing intracoronary DES implantation for unapproved indications as a group compared with outcomes after bare metal stent (BMS) placement. The clinical outcomes of 546 patients undergoing DES implantation for >= 1 non-Food

and Drug Administration-approved (“off label”) indication since the approval of the device were

assessed. The group was then matched by propensity score with 546 patients receiving BMSs prior to DES approval for the same indications. The primary endpoint was major adverse cardiac events (cardiac death, nonfatal Q-wave myocardial infarction [MI], and target vessel Selumetinib revascularization) at 12 months. Baseline clinical and angiographic characteristics were well matched between BMS and DES groups. The use of debulking devices was higher in the BMS group. Patients in the BMS group were more likely to be treated with larger diameter and shorter stents. There was no significant difference in the rate of in-hospital and 30-day

adverse cardiac events. At 12 months, the primary endpoint of major adverse cardiac events was significantly reduced in the DES group (23.6% vs 16.7%, p = 0.004), driven by reductions in the need for repeat revascularization (target lesion revascularization: 16.4% vs 7.8%, p < 0.001; target vessel revascularization: 20.2% vs 13.1%, p = 0.003). There was no significant difference in freedom from cardiac death or nonfatal Q-wave MI between groups (p = 0.27). In conclusion, the utilization of DES for non-Food and Drug Administration-approved indications proved to be efficacious and safe when compared with a BMS cohort matched by propensity score. The advantage for DES was driven by reductions in repeat revascularization. “Off-label” DES use Screening Library was not associated with increased rates of cardiac death and nonfatal MI at 12 months. (c) 2008 Elsevier Inc. All rights reserved.”
“Background: Bladder cancer is among the five most common malignancies worldwide, and due to high rates of recurrence, one of the most prevalent. Improvements in noninvasive urine-based assays to detect bladder cancer would benefit both patients and health care systems. In this study, the goal was to identify urothelial cell transcriptomic signatures associated with bladder cancer.\n\nMethods: Gene expression profiling (Affymetrix U133 Plus 2.

“
“Acrylamide is a probable human carcinogen that forms in plant-derived foods when free asparagine and reducing sugars react at high temperatures. The identification of rye varieties with low acrylamide-forming potential or agronomic conditions that produce raw material with low acrylamide precursor concentrations would reduce the acrylamide formed in baked rye foods without the need for additives or potentially costly changes to processes. This work compared five commercial Selleckchem I-BET-762 rye varieties grown under a range of fertilisation regimes to investigate the effects of genotype and nutrient (nitrogen and sulphur) availability on the accumulation of acrylamide precursors. A strong correlation was established between the

free asparagine concentration of grain and the acrylamide formed upon heating. The five rye varieties accumulated different concentrations of free asparagine in the grain, indicating that there is genetic control of this trait and GSI-IX in vitro that variety selection

could be useful in reducing acrylamide levels in rye products. High levels of nitrogen fertilisation were found to increase the accumulation of free asparagine, showing that excessive nitrogen application should be avoided in order not to exacerbate the problem of acrylamide formation. This effect of nitrogen was mitigated in two of the varieties by the application of sulphur. (C) 2013 Elsevier Ltd. All rights reserved.”
“A general method for the synthesis of a library of hitherto unreported amino-1,4-naphthoquinone-appended triazoles was accomplished via a sequential three-component reaction of substituted N-propargylaminonaphthoquinones with variously substituted alkyl bromides/2-bromonaphthalene-1,4-dione Selleck Ro 61-8048 and sodium azide in the presence of Et3N/CuI in water. Aminonaphthoquinone-appended iminochromene-triazole hybrid heterocycles were also synthesized from the amino-1,4-naphthoquinone-appended-1,2,3-triazolylacetonitriles. All the triazole hybrids were screened for their in vitro activity against Mycobacterium tuberculosis H(37)Rv (MTB). Among the triazoles, 2-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)(4-(trifluoromethyl)phenyl)amino)naphthalene-1,4-dione (7d) emerged as the most active one with IC50

= 1.87 mu M, being more potent than the anti-TB drugs, cycloserine (6 times), pyrimethamine (20 times) and equipotent as the drug ethambutol (IC50 smaller than 1.56 mu M). (C) 2014 Elsevier Masson SAS. All rights reserved.”
“Purpose: The migration of retinal pigment epithelium (RPE) cells is an initial step in the development of proliferative vitreoretinopathy (PVR). We investigated the expression of connective tissue growth factor (CTGF) in an in vitro model of wound healing and effects of recombinant human CTGF (rhCTGF) on modulating migration and Ca2+ signaling in RPE cells.\n\nMethods: Cultured human RPE monolayers were used to establish a wound healing model. Western blot and in situ hybridization were used to detect the CTGF expression in RPE cells.

Biochemical characterization of Bcr136 confirms that it is an esterase that is, however, unable to inactivate macrolides. Using steady-state kinetics, homology-based structure modeling, site-directed mutagenesis, solvent isotope effect studies, pH, and inhibitor profiling performed in various combinations for EreA, EreB, and Bcr136 enzymes, we identified the active site and gained insight into some catalytic features of this novel enzyme superfamily. We rule out the possibility of a Ser/Thr nucleophile and show that one histidine, H46 (EreB numbering),

is essential for catalytic function. This residue is proposed to serve as a general base in activation of a water molecule as the reaction nucleophile. Furthermore, we show that EreA, EreB, and Bcr136 are distinct, with only EreA inhibited by chelating agents and hypothesized to contain a noncatalytic metal. see more Detailed characterization of these esterases allows for a direct comparison of the resistance determinants, EreA and EreB, with their

prototype, Bcr136, and for the discussion of their potential connections.”
“Microfabrication technology has been adapted to produce micron-scale needles as a safer and painless alternative to hypodermic needle injection, especially for selleck inhibitor protein biotherapeutics and vaccines. This study presents a design that encapsulates molecules within microneedles that dissolve within them skin for bolus or sustained delivery and leave behind no biohazardous sharp medical waste. A fabrication process was developed based on casting a viscous aqueous solution during centrifugation to fill a micro-fabricated mold with biocompatible carboxymethylcellulose or amylopectin formulations. This process encapsulated sulforhodamine B, bovine serum albumin, and lysozyme; lysozyme was shown to retain full enzymatic

activity after encapsulation Selonsertib clinical trial and to remain 96% active after storage for 2 months at room temperature. Microneedles were also shown to be strong enough to insert into cadaver skin and then to dissolve within minutes. Bolus delivery was achieved by encapsulating molecules just within microneedle shafts. For the first time, sustained delivery over hours to days was achieved by encapsulating molecules within the microneedle backing, which served as a controlled release reservoir that delivered molecules by a combination of swelling the backing with interstitial fluid drawn out of the skin and molecule diffusion into the skin via channels formed by dissolved microneedles. We conclude that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery. (c) 2008 Elsevier Ltd. All rights reserved.”
“A 49-year-old woman developed a catatonic mute state a few weeks after methadone overdose.

In whole-cell patch clamp mode, methanol extract of Withania somnifera (mWS) induced short-lived and repeatable inward currents in all SG neurons tested (31.3 +/- 8.51 pA, n =7) using a high chloride pipette solution. Selleckchem Fer-1 The mWS-induced inward currents were concentration dependent and maintained in the presence of tetrodotoxin (TTX), a voltage gated Nachannel blocker, CNQX, a non-NMDA glutamate receptor antagonist, AP5, an NMDA receptor antagonist and strychnine, a glycine receptor antagonist. The mWS induced currents were blocked by picrotoxin, a GABAA receptor antagonist. These results show that mWS has an inhibitory

effects on SG neurons of the Vc through GABAA receptormediated activation of chloride ion channels, indicating that mWS contains compounds with sedative effects on the central nervous system. These results also suggest that mWS may be a potential target for modulating orofacial pain processing.”
“Purpose of reviewThis review focuses on the most recent studies investigating fractional nitric oxide concentration in exhaled breath

(FeNO) as a useful biomarker for identifying specific phenotypes in asthma and as a tool for asthma diagnosis, monitoring and clinical decision-making.Recent findingsOn the basis of the current literature, it has been highlighted that FeNO is a clinically relevant marker in various clinical aspects of asthma: FeNO is a predictor for developing asthma in persistent rhinitis or in infants with respiratory symptoms; FeNO contributes to identification of asthma phenotypes in both children and adults, also in NSC23766 clinical trial relation to severity; FeNO is useful in monitoring the effectiveness of inhaled corticosteroids (including compliance) and biologic treatments like omalizumab; FeNO, in conjunction with symptom registration and lung function measurements, contributes to asthma diagnosis and optimizes asthma management.SummaryFeNO provides further information in distinguishing different phenotypes in asthma, allowing a much more appropriate click here control of the disease, especially in patients with difficult/severe asthma. In the future, it would be interesting to shed light on

the hidden biological mechanisms responsible for low or normal FeNO values in symptomatic asthmatic patients.”
“PurposeThe multiband (MB) excitation and reconstruction technique was both developed and evaluated for accelerated data acquisition of arterial spin labeling (ASL) to cover whole brain perfusion maps.\n\nTheory and MethodsMB excitation was incorporated into a pulsed ASL (PASL) technique and compared with conventional single-band excitation PASL from healthy subjects, using a 32-channel head receiver coil at 3 T. The MB de-aliasing performance and effectiveness in perfusion measurement were measured with varying MB acceleration factors and gaps between MB excitations.\n\nResultsThe MB PASL perfusion maps were in good agreement with the conventional single-band PASL maps at matched slices.

05) and total a-actin content was 45% higher in the Moderate group and 65% (P < 0.05) higher in the Severe group, compared to Control. A 12% and 39% (P < 0.05) reduction in relative elastic fibre content was observed in Moderate and Severe fetuses, respectively. mRNA levels EPZ5676 of the elastolytic enzyme, matrix metalloproteinase-2 (MMP-2) were inversely correlated with fetal arterial oxygen saturation

(P < 0.05) (Fig. 7) and mRNA levels of its activator, membrane-type MMP (MTI-MMP), were elevated in the Severe group (P < 0.05). Marked neointima formation was apparent in Severe fetuses (P < 0.05) concomitant with an increase in E-selectin mRNA expression (P < 0.05). Thus, aberrant aortic formation in utero mediated by molecular regulators of arterial growth occurs

in response to chronic hypoxaemia.”
“Meningococcal disease frequently presents neurologic selleckchem sequels via vascular, metabolic, or inflammatory processes. Understanding the underlying pathogenic mechanisms may influence both treatment and outcome. We present a 2-year-old child affected by Neisseria meningitidis sepsis, who on the second day from clinical onset manifested recurrent partial motor seizures and focal neurologic signs. An early magnetic resonance angiography of the circle of Willis produced normal results, whereas magnetic resonance imaging of the brain disclosed cortical signal abnormalities consistent with cytotoxic edema, without involvement of the adjacent white matter. Six-month follow-up magnetic resonance imaging of the brain indicated faint cortical atrophy in the same regions, although the neurologic picture had resolved. The literature contains few data on early magnetic resonance parenchymal changes, and their pathogenic mechanism is controversial. Diffusion-weighted images may contribute to an understanding of the mechanisms of such brain damage. (C) 2009 by Elsevier

Inc. All rights reserved.”
“The transcription factor E2F1 is active during Cl to S transition and is involved in the cell cycle and progression. A recent study reported that increased E2F1 is associated with DNA damage and tumor development selleck products in several tissues using transgenic models. Here, we show that E2F1 expression is regulated by tristetraprolin (TTP) in prostate cancer. Overexpression of TTP decreased the stability of E2F1 mRNA and the expression level of E2F1. In contrast, inhibition of TTP using siRNA increased the E2F1 expression. E2F1 mRNA contains three AREs within the 3′UTR, and TTP destabilized a luciferase mRNA that contained the E2F1 mRNA 3′UTR. Analyses of point mutants of the E2F1 mRNA 3′UTR demonstrated that ARE2 was mostly responsible for the TTP-mediated destabilization of E2F1 mRNA. RNA EMSA revealed that TTP binds directly to the E2F1 mRNA 3′UTR of ARE2. Moreover, treatment with siRNA against TTP increased the proliferation of PC3 human prostate cancer cells.

\n\nConclusion. Targeting HSP90 does not negatively affect the multifactorial process of liver regeneration and repair in vivo. Hence, the use of inhibitors to HSP90 appears to be a valid option for neoadjuvant therapy of liver metastases when subsequent surgery is intended.

(Surgery 2010;147:704-12.)”
“During a study of endophytic bacteria from coastal dune plants, a bacterial strain, designated YC6881(T), selleck screening library was isolated from the root of Rosa rugosa collected from the coastal dune areas of Namhae Island, Korea. The bacterium was found to be Gram-staining-negative, motile, halophilic and heterotrophic with a single polar flagellum. Strain YC6881(T) grew at temperatures of 4-37 degrees C (optimum, 28-32

degrees C), at pH 6.0-9.0 (optimum, pH 7.0-8.0), and at NaCl concentrations in the range of 0-7.5% (w/v) (optimum, 4-5% NaCl). Strain YC6881(T) was catalase- and oxidase-positive and negative for nitrate reduction. According to phylogenetic analysis using 16S rRNA gene sequences, strain YC6881(T) belonged to the genus Rhizobium and showed the highest 16S rRNA gene sequence similarity of 96.9% to Rhizobium rosettiformans, followed by Rhizobium borbori (96.3 %), Rhizobium radiobacter (96.1 %), Rhizobium daejeonense check details (95.9 %), Rhizobium larrymoorei (95.6 %) and Rhizobium giardinii (95.4%). Phylogenetic analysis of strain YC6881(T) by recA, atpD, glnII and 16S-23S intergenic spacer (IGS) sequences all confirmed the phylogenetic arrangements obtained by using 16S rRNA gene sequences. Cross-nodulation tests showed that strain

YC6881(T) was a symbiotic bacterium that nodulated Vigna unguiculata and Pisum sativum. The major components of the cellular fatty acids were C-18:1 omega 7c (53.7%), C-19:0 cyclo omega 8c (12.6%) and C-12:0 (8.1 %). The DNA G+C content was 52.8 mol%. Phenotypic and physiological tests with respect to carbon source utilization, antibiotic resistance, growth conditions, phylogenetic analyses of housekeeping genes recA, atpD and glnII, and fatty acid composition could be used to discriminate strain YC6881(T) from other species of the genus Rhizobium in the same sublineage. Based on the results obtained selleck kinase inhibitor in this study, strain YC6881(T) is considered to represent a novel species of the genus Rhizobium, for which the name Rhizobium halophytocola sp. nov. is proposed. The type strain is YC6881(T) (=KACC 13775(T)=DSM 21600(T)).”
“Aging men and women display both increased incidence of cardiovascular disease and complications of myocardial infarction and heart failure. We hypothesized that altered glucose metabolism, in particular, flux of glucose via the polyol pathway (PP) may be responsible, in part, for the enhanced vulnerability of aging myocardium to ischemic injury, even in the absence of superimposed disease processes linked to PP flux, such as diabetes.

5 to 24 hours after

oral administration of sub-lethal doses of praziquantel. Genes up-regulated initially in male parasites were associated with “Tegument/Muscle Repair” and “Lipid/Ion Regulation” functions and were followed by “Drug Resistance” and “Ion Regulation” associated genes. Prominent responses induced in female worms included upregulation of “Ca2+ Regulation” and “Drug Resistance” genes and later by transcripts of “Detoxification” and “Pathogen Defense” mechanisms. A subset of highly over-expressed genes, with putative drug resistance/detoxification roles or Ca2+-dependant/modulatory functions, were validated by qPCR. The leading candidate among these was CamKII, a putative calcium/calmodulin-dependent protein kinase type II delta chain. RNA AZD7762 concentration interference was employed to knockdown CamKII in S. japonicum to determine the role of CamKII Caspase inhibitor in vivo in the response to praziquantel. After partial-knockdown, schistosomes were analysed using IC50 concentrations (50% worm motility) and quantitative

monitoring of parasite movement. When CamKII transcription was reduced by 50-69% in S. japonicum, the subsequent effect of an IC50 dosage of praziquantel was exacerbated, reducing motility from 47% to 27% in female worms and from 61% to 23% in males. These observations indicated that CamKII mitigates the effects of praziquantel, probably through stabilising Ca2+ fluxes within parasite muscles and tegument. Together, these studies comprehensively charted transcriptional changes upon exposure to praziquantel and, notably, identified CamKII as potentially QNZ chemical structure central to the, as yet undefined, mode of action of praziquantel.”
“OBJECTIVES To characterize ultrasound bladder measures, and to determine whether these measures were associated with measures of lower urinary tract dysfunction.\n\nMETHODS Three-dimensional ultrasounds were used to assess bladder surface area (SA), bladder wall thickness (BWT), and estimated

bladder weight (EBW) in a random sample of the Olmsted County, Minnesota, male population. Uroflowometry was used to determine maximum urinary flow rates, and ultrasound was used to assess postvoid residual volume. Prostate volume was assessed with transrectal ultrasound and prostate-specific antigen (PSA) levels were assessed from serum samples. Correlation and linear regression analyses assessed relationships between bladder measures and prostate volume, PSA, maximum flow rate, and postvoid residual.\n\nRESULTS Among 259 men, median bladder SA was 228 cm(2) (25th, 75th percentiles: 180, 279), median BWT was 2.3 mm (25th, 75th percentiles: 1.8, 2.7), and median EBW was 48.5 g (25th, 75th percentiles: 43.7, 53.0). Decreased bladder SA was correlated with increased PSA level, increased prostate volume, higher American Urological Association Symptom Index (AUASI) scores (r(s) = -0.13 to -0.21; P =.03-.

13% were already obese. 50.56% of the students practiced very little weekly physical activity. The median of daily sedentary lifestyle was 12 hours, with an interquartile range of 4 hours. A statistically significant association was found CB-839 between excessive weight and sedentary behavior, according to the total

fat method (adjusted OR: 1.11, CI 95%: 1.01-1.23). Conclusions: College students’ health behavior is often inadequate in terms of physical activity and dietary habits. Our study observed an association between physical inactivity and excessive weight. Physical inactivity is an important lifestyle factor related to chronic diseases. Further research should focus on determinants to increase their physical activity and to improve their daily lifestyle in order to lower the risk of future diseases.”
“[Purpose] To investigate the sensitivity and specificity of a newly developed diagnostic tool, the Amer Dizziness Diagnostic Scale (ADDS), to evaluate

and differentially diagnose vestibular disorder and to identify the strengths and weaknesses of the scale and its usefulness in clinical practice. [Subjects and Methods] Two hundred subjects of both genders (72 males, 128 females) aged between 18 to 60 (49.5 +/- 7.8) who VX-689 had a history of vertigo and/or dizziness symptoms for this previous two weeks or less were recruited for the study. All subjects were referred by otolaryngologists, neurologists or family physicians in and around Jeddah, Kingdom of Saudi Arabia. On the first clinic visit, all the patients were evaluated once using the ADDS, following which they underwent routine testing of clinical signs and symptoms, audiometry, LY2835219 price and a neurological examination, coupled with tests of Vestibulo-Ocular Reflex function, which often serves as the “gold standard” for determining the probability of a vestibular deficit. [Results] The results show that the ADDS strongly correlated with “true-positive” and “true-negative” responses for determining the probability of a vestibular disorder (r = 0.95). A

stepwise linear regression was conducted and the results indicate that the ADDS was a significant predictor of “true-positive” and “true-negative” responses in vestibular disorders (R-2 = 0.90). Approximately 90% of the variability in the vestibular gold standard test was explained by its relationship to the ADDS. Moreover, the ADDS was found to have a sensitivity of 96% and a specificity of 96%. [Conclusion] This study showed that the Amer Dizziness Diagnostic Scale has high sensitivity and specificity and that it can be used as a method of differential diagnosis for patients with vestibular disorders.”
“Genome wide hypomethylation and regional hypermethylation of cancer cells and tissues remain a paradox, though it has received a convincing confirmation that epigenetic switching systems, including DNA-methylation represent a fundamental regulatory mechanism that has an impact on genome maintenance and gene transcription.

Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1908-1918; doi:10.1038/jcbfm.2011.60; published online 11 May 2011″
“Background: Palliative care should be provided, irrespective of setting to all patients facing a life-threatening LY3039478 manufacturer illness and to their families. The situation and needs of order people differ from those of younger people since they often have several co-existing diseases and health complaints. This implies an extensive need for care and for longer periods of palliative care. The main providers of palliative care for older people are nurse assistants, who are also those with the shortest education.\n\nAim: The aim of this

study was to illuminate nurse assistants’ experience of palliative care for older people in residential care.\n\nDesign: The study had an explorative, descriptive design.\n\nSettings: Thirteen residential care units BTSA1 in three different districts in a large city in southern Sweden.\n\nParticipants: Twenty-five nurse assistants selected to represent variations in age, gender workplace and work experience.\n\nMethods: Data were collected from six focus-group interviews and subjected to content analysis to gain an understanding of the phenomenon.\n\nResults: The nurse assistants described palliative

care as a contrast to the everyday care they performed in that they had a legitimate possibility to provide the care needed and a clear assignment in relation to relatives. Palliative care also meant having to face death and dying while feeling simultaneous that it was unnatural to talk about death and having to deal with their own emotions. They emphasised that they were in need of support and experienced leadership as invisible and opaque, but gained strength from being recognized.\n\nConclusion: In order to support nurse assistants in providing high quality end-of-life care, more focus is needed on the trajectory of older peoples’ dying, on the importance of involving relatives throughout the period of care

provision, and on support when encountering death and dying. There is also a need for engaged care leaders, both registered nurses and managers, to recognize the work of nurse assistants and to support care provision for older people within the framework of palliative care philosophy. (C) 2011 Elsevier Ltd. All rights reserved.”
“Eukaryotic CRT0066101 purchase protein kinases (ePKs) evolved as a family of highly dynamic molecular switches that serve to orchestrate the activity of almost all cellular processes. Some of the functionally characterized ePKs from plants have been found to be components of signaling networks, such as those for the perception of biotic agents, light quality and quantity, plant hormones, and various adverse environmental conditions. To date, only a tiny fraction of plant ePKs have been functionally identified, and even fewer have been identified in maize [Zea mays (Zm)]. In this study, we have identified 1,241 PK-encoding genes in the maize genome.

Abnormal epigenetic re-programming appears to be a key component of the observed pathologies, as shown by studies on the expression of imprinted genes in SCNT placenta. (C) 2012 Published by IFPA and Elsevier Ltd.”
“A rational strategy has been used to immobilize open metal sites in ultramicroporosity for

stronger binding of multiple H-2 molecules per unsaturated metal site for H-2 storage applications. The synthesis and structure of a mixed zinc/copper metal-organic framework material Zn-3(BDC)(3)[CU(Pyen)] center dot(DMF)(5)(H2O)(5) (H2BDC = 1,4 benzenedicarboxylic acid and PyenH(2) = 5-methyl-4-oxo-1,4-dihydro-pyridine-3-carbaldehyde) is reported. Desolvation provides a bimodal porous structure Zn-3(BDC)(3)[Cu(Pyen)] (M’MOF 1) with narrow porosity (<0.56 nm) and an array of pores in the bc crystallographic plane where the adsorbate-adsorbent interactions are maximized by both the presence

of open copper centers and Repotrectinib datasheet overlap of the potential energy fields from pore walls. The H-2 and D-2 adsorption isotherms for M’MOF 1 at 77.3 and 87.3 K were reversible with virtually no hysteresis. Methods for determination of the isosteric enthalpies of H-2 and D-2 adsorption were compared. A virial see more model gave the best agreement (average deviation <1 standard deviation) with the isotherm data. This was used in conjunction with the van’t Hoff isochore giving isosteric enthalpies at zero surface coverage of 12.29 +/- 0.53 and 12.44 +/- 0.50 kJ mol(-1) for H-2 and D-2 adsorption, respectively. This is the highest value so far observed for hydrogen adsorption on a porous material. The enthalpy of adsorption, decreases with increasing Etomoxir research buy amount adsorbed to 9.5 kJ mol(-1) at similar to 1.9 mmol g(-1) (2 H-2 or D-2 molecules per Cu corresponding to adsorption on both sides of planar Cu open centers) and is virtually unchanged in the range 1.9-3.6 mmol g(-1). Virial analysis of isotherms at 87.3 K is also consistent with

two H-2 or D-2 molecules being bound to each open Cu center. The adsorption kinetics follow a double exponential model, corresponding to diffusion along two types of pores, a slow component with high activation energy (13.35 +/- 0.59 kJ mol(-1)) for the narrow pores and a faster component with low activation energy (8.56 +/- 0.41 kJ mol(-1)). The D-2 adsorption kinetic constants for both components were significantly faster than the corresponding H-2 kinetics for specific pressure increments and had slightly lower activation energies than the corresponding values for H-2 adsorption. The kD(2)/kH(2) ratio for the slow component was 1.62 +/- 0.07, while the fast component was 1.38 +/- 0.04 at 77.3 K, and the corresponding ratios were smaller at 87.3 K. These observations of kinetic isotope quantum molecular sieving in porous materials are due to the larger zero-point energy for the lighter H-2, resulting in slower adsorption kinetics compared with the heavier D-2.