Of those, 2,334 had NAFLD. After 179 months of follow-up, the overall mortality was 20% (N=467). Five most common causes of death in NAFLD were cardiovascular-respiratory diseases (41.5%),
solid organ malignancies excluding liver (21.0%), diabetes mellitus 32 (5.3%), and chronic liver diseases (3.17%). NFS was found to be independently associated with mortality: adjusted hazard ratio (aHR) = 1.361 (p<0.0001). After additional adjustment for age, the association of NFS with overall mortality remained significant (aHR=1.146, p<0.0001). Furthermore, in a series of survival analyses with different thresholds for NFS ranging from -5 to 5, we determined the best possible thresholds for NFS for the association with overall mortality. These survival analyses showed that NFS remained associated with mortality between a score of -1.80 (aHR=1.276, p=0.0498), and 1.25 (aHR=1.607, p=0.0203). The most significant JQ1 supplier association of NFS with mortality was found for a NAFLD Fibrosis score of 0.75 (aHR=1.775, p=0.0004). CONCLUSIONS: The well-established NAFLD Fibrosis Score is associated with overall mortality even after adjustment
for age. The threshold for NFS that would return the outcome with best association with mortality in NAFLD cohort is 0.75 which is close to 0.68 suggested by the authors for ruling-in fibrosis in NAFLD patients. Disclosures: Zobair M. Younossi – Advisory Committees or Review Panels: Merck, Vertex, Tibotec/J and J; Consulting: Loperamide Gilead Sciences The following
people have nothing to disclose: Maria Stepanova, Linda Henry, James N. Cooper, Shirley K. Kalwaney, Chapy Venkatesan, Alita Mishra Purpose: The aims of learn more this study were to determine the influence of excessive alcohol consumption on hepatocarcinogenesis and the risk factors for hepatocellular carcinoma (HCC) and to elucidate the utility of non-invasive predictive procedures for liver fibrosis, such as the FIB4-index, in the prediction of HCC in a large population of Japanese fatty liver patients without viral hepatitis. Methods: This was a retrospective cohort study conducted at a public hospital. Study subjects included 6,621 patients with non-alcoholic fatty liver disease (NAFLD) and 946 patients with alcoholic fatty liver disease (AFLD; daily alcohol consumption >70 g) diagnosed by ultrasonography. The median follow-up period was 5.9 years. The primary endpoint was onset of HCC. Evaluation was performed using Kaplan-Meier methodology and Cox proportional hazards analysis. Results: In NAFLD patients, there were 19 (0.29%) cases of newly diagnosed HCC, and the cumulative rates of NAFLD-related HCC were 0.05% at year 4, 0.21% at year 8, and 0.63% at year 12. In contrast, in AFLD patients, there were 18 (1.9%) cases diagnosed with HCC, and the cumulative rates of AFLD-related HCC were 0.67%, 1.89%, and 2.6%, respectively. The annual incidence of HCC was 0.05% and 0.22%, respectively.