11,12 Use of anticoagulant medication during elective and primary percutaneous coronary intervention has been generally supported by previous research.13 Researchers have long been evaluating the incidence of the hemorrhagic complications of heparin in coronary angiography as opposed to its protective effects on reducing ischemic coronary events during and after angiography. We aimed to assess the advantages and disadvantages of heparin administration during coronary angiography with respect to clot formation as well as vascular,

ischemic, and hemorrhagic complications. Inhibitors,research,lifescience,medical Patients and Methods This single-blind, randomized controlled trial was conducted in Ekbatan Hospital, in the western Iranian city of Hamadan, between 2007 and 2008. The trial was approved by the local Human Subject Review Board of Hamadan University of Medical Sciences (No: 4226) and indexed by the Iranian Register of Clinical Inhibitors,research,lifescience,medical Trials (No: 201202199080N1). The patients all volunteered

to enroll in the study and signed written informed consent (figure 1). Figure 1 This flow diagram depicts the progress through the phases of this parallel randomized trial of the two study groups. We enrolled Inhibitors,research,lifescience,medical all patients with CAD who were referred to Ekbatan Hospital for coronary angiography with the following criteria: (1) typical chest pain; (2) positive exercise test; (3) regional wall motion abnormality in echocardiography;

(4) positive gated Inhibitors,research,lifescience,medical technetium 99m sestamibi single emission computed tomography (Tc99m-MIBI-SPECT); (5) previous history of Coronary Care Unit (CCU) admission due to acute coronary syndrome; Inhibitors,research,lifescience,medical and (6) history of myocardial infarction. Patients with the following criteria were excluded from the study: (1) mean severe aortic stenosis; (2) severe peripheral vascular disease; (3) history of coagulopathy; and (4) duration of Nilotinib Leukemia angiographic procedure more than 30 minutes. Based on statistical formulae and considering a 10% probability GSK-3 of dropout, a sample of 500 patients was estimated for this study. The patients were randomized into two equal intervention (receiving heparin) and control (receiving placebo) groups using a systematic method so that the first patient was randomly assigned to one of the two groups through coin tossing and then the subsequent patients were assigned to either group one at a time. The study was conducted using a single-blind design, and while the researchers knew which patients had been assigned to the intervention or control groups, the patients were not aware of the administered intervention.