ZrB2 could then be formed by the direct reaction between

Zr and B. Finally, the ZrB2-Al2O3 composite powders were obtained. Furthermore, a model corresponding to the dissolution precipitation mechanism was proposed. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All selleck kinase inhibitor rights reserved.”
“Drug-free microparticles were prepared using a spray congealing process with the intention of studying the influence of processing parameters. By varying the atomizing pressure and liquid feed rate, microparticles with median sizes (d((0.5))) from 58 to 278 mu m were produced. with total process yields ranging from 81% to 96%. An increased liquid feed rate was found to increase microparticle size, and higher atomizing pressures were found to decrease microparticle size. Greater change in microparticle size was achieved by varying atomizing pressure, which can be considered a dominant process parameter

regarding microparticle size. In addition. microparticles with glimepiride, a model poorly water-soluble drug, were prepared by spray congealing using three different hydrophilic meltable carriers: Gelucire (R) 50/13, poloxamer 188, and PEG 6000. Spherical microparticles with relatively smooth surfaces were obtained, with no drug crystals evident on the surfaces of drug-loaded microparticles. XRPD showed no change in crystallinity of the drug due to the technological process of microparticle production. All glimepiride-loaded microparticles LY411575 in vitro showed enhanced solubility compared to pure drug; however, check details Gelucire (R) 50/13 as a carrier represents the most promising approach to the dissolution rate enhancement

of glimepiride. The influence of storage (30 degrees C/65% RH for 30 days) on the morphology of glimepiride/Gelucire (R) 50/13 microparticles was studied, and the formation of leaf-like structures was observed (a “blooming” effect). (C) 2009 Elsevier B.V. All rights reserved.”
“Plasmodium falciparum causes the most severe form of malaria and is responsible for the majority of deaths worldwide. The mechanism of cell cycle control within intra-erythrocytic stages has been examined as a potential means of a promising way to identifying how to stop parasite development in red blood cells. Our group determined that melatonin increases parasitemia in P.falciparum and P.chabaudi through a complex signalling cascade. In vertebrates, melatonin controls the expression of transcription factors, leading us to postulate rather that the indoleamine would affect PfNF-YB expression in human malaria parasites. We show here that PfNF-YB transcription factor is highly expressed and colocalized in the nucleus in mature parasites during intra-erythrocytic stages, thus suggesting an important role in cell division. Moreover, we demonstrate for the first time that melatonin and cAMP modulate the PfNF-YB transcription factor expression in P.falciparum at erythrocytic stages.