There is substantial evidence that certain SGAs are associated with clinically significant weight gain, increased risk for insulin resistance, hyperglycemia, type 2 diabetes

mellitus and buy BVD-523 dyslipidemia compared with first-generation antipsychotics [Allison et al. 1999; Newcomer, 2005; Fleischhacker et al. 2008]. There are very few data available on metabolic effects of amisulpride. Recent reviews concluded that amisulpride is associated with minimal weight change, ranging between 0.2 and 1.4 kg over varying treatment durations [Russell and Mackell, 2001; Tschoner et al. 2007]. Amisulpride appears to have less risk of treatment-emergent dyslipidemia in comparison with Inhibitors,research,lifescience,medical olanzapine and clozapine [Newcomer, 2005; Rettenbacher et al. 2007]. In the study of Tschoner and colleagues, olanzapine

and clozapine were found to constitute Inhibitors,research,lifescience,medical a high-risk group for metabolic dysregulation while amisulpride, quetiapine, risperidone and ziprasidone could be assigned to a non-high-risk group [Tschoner et al. 2009]. Subjects from the high-risk group displayed Inhibitors,research,lifescience,medical significant weight gain with concomitant increases in levels of insulin, total cholesterol, triglyceride (TG), low-density lipoprotein (LDL) and leptin. No significant changes were observed in the non-high-risk group. Information on the cardiovascular safety and tolerance of antipsychotics is of significant clinical importance because antipsychotics can promote cardiac arrhythmias, which are anomalies implicated as a cause of sudden death among antipsychotic-treated patients [Ungvári, 1982; Brown and Kocsis, 1984; Dunne, 1994]. Rein and colleagues stated that electrocardiographic data of 341 patients in long- and short-term studies revealed Inhibitors,research,lifescience,medical no QTc prolongation with amisulpride [Rein et al. 2000]. In the study of Agelink and colleagues, the neuro-cardiac effects of four so-called Inhibitors,research,lifescience,medical atypical antipsychotics (amisulpride, olanzapine, clozapine and sertindole) were compared [Agelink et al. 2001]. An increase in mean resting heart rate was seen during

treatment with all drugs but amisulpride. Electrocardiogram showed that all antipsychotics except Casein kinase 1 for amisulpride tended to prolong mean QTc times, prolongation of which increases the risk of ventricular tachycardia. Although safe in regular doses, it is reported that amisulpride overdose is associated with QT prolongation and torsades de pointes [Lynch et al. 2008; Isbister et al. 2010]. In this study we aimed to determine endocrinologic, metabolic and cardiac effects of amisulpride, which is commonly used in our clinical practice. Materials and methods A total of 21 patients (12 males, 9 females) referred to the Psychiatry Department of Uludag University Medical Faculty were enrolled in the study and 18 of them (11 males, 7 females) completed the study.