The results indicate substantial differences between the analyzed data, which point out the needs of differentiated actions for providing adequate pharmaceutical care.”
“Chorioamnionitis is the inflammatory response to an acute inflammation of the membranes and chorion of the placenta. We provide a critical review of the relationship between chorioamnionitis and the risk of prematurity and adverse maternal-fetal outcome. Chorioamnionitis results as a major risk factor for preterm birth and its incidence is strictly related to gestational age. It is associated with a significant maternal, perinatal and long-term

adverse outcomes. check details The principal neonatal complications are neonatal sepsis, pneumonia, bronchopulmonary dysplasia, perinatal

death, cerebral palsy and intraventricular hemorrhage. The role in neonatal outcome is still controversial and more conclusive studies could clarify the relationship between chorioamnionitis Saracatinib inhibitor and adverse neonatal outcome. Maternal complications include abnormal progression of labour, caesarean section, postpartum hemorrhage, abnormal response after use of oxytocin and placenta abruption. Prompt administration of antibiotics and steroids could improve neonatal outcomes.”
“”"Evaluation of Acute Oral Toxicity and Diuretic Activity of Rudgea viburnoides (Cham.) Benth. (congonha-de-bugre)”". Rudgea viburnoides is popularly used as anti-hypertensive, anti-rheumatic, antissifilitic, blood depurative and for treatment of dyspepsia (leaves, bark, tea). The

acute toxicity of ethanolic extract (EEBFRV) in single dose was performed by gavage of doses of 2000 and 5000 mg/kg in Swiss mice and Wistar rats, both sexes, by the class test. To diuretic activity YM155 in Wistar rats, it was used the EEBFRV at the doses of 40, 80 and 160 mg/kg, furosemide 20 mg/kg (control +), and saline solution 0.9 % (control -). Regarding acute toxicity, no mortality and no toxicity signs at the dose levels were observed, indicating low toxicity of the extract. The EEBFRV showed statistically significant dose-dependent diuretic effect in 24 h, increasing all parameters evaluated (24h urine volume, excretion of Na(+), K(+) and Cl(-) electrolytes, urea (BUN) and creatinine). Thus, the results so far may justify the popular use of Rudgea viburnoides as diuretic.”
“The high incidence of neonatal sepsis worldwide and the considerably high mortality rate of severe sepsis and septic shock call for an earlier diagnosis and more accurate monitoring of the disease.