Materials and Methods: This cross-sectional study was done at 3 tertiary referral centers for childhood urinary incontinence. The self-reported and proxy English version was translated and cross-culturally adapted. From July 2007 to April 2008 we evaluated the German version in 91 boys and 54 girls w ith a mean +/- SD age of 9.3 +/- 2.2 years (range 6 to 18) with nonneurogenic urinary incontinence and in their parents. For concurrent criterion related validity, the German questionnaire scales were compared with those of the DCGM-10/-12.
Results: On reliability testing of the self-reported and proxy German versions Cronbach’s a was
0.84 and 0.86, respectively. Interrater convergence between the self-reported and proxy versions showed an ICC of 0.81. Reproducibility was satisfactory CH5183284 manufacturer for the self-reported and proxy versions (ICC 0.77, 95% CI 0.77-0.90 and 0.85, 95% CI 0.67-0.84, respectively). German version scores correlated with DCGM-10/-12 scores (self-report and proxy r = -0.71 and -0.69, respectively). Mean German version total scores were 23.0 in boys and 23.9 in girls. Except for a slight significant association between age and German version total score in the proxy version (p = 0.01), age, sex and incontinence type or severity (number of wet days/nights
per 14 days) were not significantly associated with German version total scores.
Conclusions: The German version of the Pediatric Incontinence Questionnaire is a valid and reliable outcome measure to NSC23766 mouse assess health related quality of life in children and adolescents with urinary incontinence.”
“In the adult rat hippocampal formation,
neurogenesis occurs in the dentate gyrus subgranular zone (SGZ). We used laser capture microdissection and an antidepressant-related genes microarray to analyze gene expression profiles of cells from the SGZ and from the outermost granule cell layer. Of the differentially expressed genes in the SGZ, we focused on neuroserpin, which is highly expressed in the adult rat SGZ Neuroserpin immunoreactivity was present in cells positive for NeuN (postmitotic cell marker) and Tuj1 (immature neuron marker) but not in cells positive for calbindin (mature neuron marker). Although neuroserpin is expressed during late stage SDHB of neurogenesis in development our results suggest that neuroserpin may play some roles in early stage of neurogenesis in adult rat hippocampus. NeuroReport 21:138-142 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.”
“Purpose: We evaluated health related quality of life of pediatric patients with nonneurogenic urinary incontinence and determined potential influencing factors. Also, health related quality of life results in our sample were compared to those of other chronic childhood health conditions.