Key messages? The f/Vt

Key messages? The f/Vt selleck Dorsomorphin ratio remains one of the best predictors of weaning outcome.? IWI is an index that comprises respiratory system compliance, which informs about the mechanical condition of the lungs and chest wall; SaO2, which provides information about the patients’ capacity to maintain a desirable oxygenation and f/Vt ratio, which informs about the patients’ capacity to maintain unassisted breathing, evaluating the weaning outcome with better accuracy.? IWI was useful to detect those patients who passed the SBT but needed reintubation afterwards.? In our population, IWI was the best index to predict the weaning outcome.

AbbreviationsCOPD: chronic obstructive pulmonary disease; CROP: acronym of compliance, rate, oxygenation and pressure; Cst,rs: static compliance of the respiratory system; DA: diagnostic accuracy; FiO2: fraction of inspired oxygen; f: respiratory rate; f/Vt ratio: frequency to tidal volume ratio; ICU: intensive care unit; IWI: integrative weaning index; LR+: likelihood ratio of positive test; LR-: likelihood ratio of negative test; MIP: maximal inspiratory pressure; NPV: negative predictive value; P 0.1: airway occlusion pressure; PaCO2: partial pressure of arterial carbon dioxide; PaO2/FiO2 ratio: ratio of arterial oxygen tension to fraction of inspired oxygen; PEEP: positive end expiratory pressure; PPV: positive predictive value; P(W+/T+): probability for weaning success if test is positive; P(W+/T-): probability for weaning success if test is negative; ROC: receiver operator curve; RSBI: rapid shallow breathing index; SaO2: arterial oxygen saturation; SBT: spontaneous breathing trial; SE: sensitivity; SP: specificity; Vt: tidal volume.

Competing interestsThe authors declare that they have no competing interests.Authors’ contributionsAll authors, except RN, equally contributed to the design, data acquisition and manuscript preparation. RN (from the Biostatistics Department of Federal University of Rio d Janeiro – Rio de Janeiro – Brazil) wrote the statistical analysis.NotesSee related commentary by Epstein, http://ccforum.com/content/13/5/197AcknowledgementsThe authors are thankful to the respiratory physiotherapists (Cl��udia Savedra, Cl��udia Cadilhe, Cl��udia Geraldo, Juliani Goulart, L��a Ferreira, Lara Tabajaras, L��lian Par��zo, Luciene Caldeira, M��rcius Rocha, L��via Os��rio, C��tia Coimbra, Eduardo Faria, Jordan Brust, Juliana Dias, Luis Silva, Luis Almeida, Michelle Cabral, Rafael Maia, Rodrigo ��vila, Paulo Reis, Soraya Machado, Monclar Ramalho, Vladimir Nery, Vin��cus Nery, Victor Carvalho, Elaine ��vila, Marcelo Andrade and Thiago Clipes) and physicians (especially to Dr.

Jorge Isidoro Lain, Cilengitide Dr. Jo?o Andrade and Dr. Moyz��s Damasceno) of the Intensive Care Unit of the Hospital de Cl��nicas de Niter��i, for their collaboration and dedication in our study.
Acute lung injury (ALI) and sepsis have a close relation in the intensive care unit (ICU) setting.

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