J Bone Miner Res 6:883–892PubMedCrossRef BLZ945 21. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559–575PubMedCrossRef 22. Li Y, Abecasis GR (2006) Mach 1.0: Rapid Haplotype Reconstruction and Missing Genotype Inference. Am J Hum Genet S79:2290 23. Hahn LW, Ritchie MD, Moore JH (2003) Multifactor dimensionality reduction software for detecting gene–gene and gene–environment interactions. Bioinformatics 19(3):376–382PubMedCrossRef 24. Yuan HY, Chiou JJ, Tseng WH, Liu CH, Liu CK, Lin YJ, Wang

HH, Yao A, Chen YT, Hsu CN (2006) FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. Nucleic Acids Res 34:W635–W641PubMedCrossRef 25. Cordey J, Schneider Selleckchem AC220 M, Belendez C, Ziegler WJ, Rahn BA, Perren SM (1992) Effect of bone size, not density, on the stiffness of the proximal part of normal and osteoporotic human femora. J Bone Miner Res 2:S437–S444CrossRef 26. Tabensky AD, Williams J, DeLuca V, Briganti E, Seeman E (1996) Bone mass, areal, and volumetric bone density are equally accurate, sensitive, and specific surrogates of the breaking strength of

the vertebral body: an in vitro study. J Bone Miner Res 11:1981–1988PubMedCrossRef 27. Kaufman JM, Ostertag A, Saint-Pierre A, Cohen-Solal M, Boland A, Van Pottelbergh I, Toye K, de Vernejoul MC, Martinez M (2008) Genome-wide linkage screen of bone mineral density (BMD) in European pedigrees ascertained through a male relative with low BMD values: evidence for quantitative trait loci on 17q21-23, 11q12-13, 13q12-14, and 22q11. J Clin Endocrinol Metab 93:3755–3762PubMedCrossRef 28. Kiel DP, Demissie S, Dupuis J, Lunetta KL, Murabito JM, Karasik D (2007) Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet 1:S14CrossRef 29. Lindsley A, Snider P, Zhou H, Rogers R, Wang J, Olaopa M, Kruzynska-Frejtag A, Koushik SV, Lilly B, Burch JB, Firulli AB, Conway SJ (2007)

Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer. Dev Biol 307:340–355PubMedCrossRef 30. Guo RJ, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, Klein RVX-208 P, Suh ER, Lynch JP (2004) Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J Biol Chem 279:36865–36875PubMedCrossRef 31. Subramanian V, Meyer BI, Gruss P (1995) Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell 83:641–653PubMedCrossRef 32. Gersch RP, Lombardo F, McGovern SC, Hadjiargyrou M (2005) Reactivation of Hox gene expression during bone regeneration. J Orthop Res 23:882–Selleck EPZ 6438 890PubMedCrossRef 33.