In HIV-1-uninfected women, the data regarding the effect of screening for and treating BV find more on premature delivery are conflicting. As outlined above, in HIV-positive pregnant women there

are additional considerations regarding the potential effect of genital infections on MTCT of HIV-1, but these data are largely from the pre-cART era. In the setting of full virological suppression on cART it is unclear to what extent, if any, the presence of any genital infection will contribute to HIV MTCT. Newly diagnosed HIV-positive pregnant women should be screened for sexually transmitted infections as per the routine management of newly diagnosed patients [48]. For pregnant HIV-1-positive women already engaged in HIV care, in the absence of randomized controlled trials but for the reasons outlined above, the Writing Group suggests screening for genital tract infections including evidence of BV. This should be done as early as possible in pregnancy and

consideration should be given to repeating this PF-02341066 datasheet at around 28 weeks. Syphilis serology should be performed on both occasions. In addition, any infection detected should be treated according to the BASHH guidelines (www.bashh.org/guidelines), followed by a test of cure. Partner notification should take place where indicated, to avoid re-infection. With regard to cervical cytology, HIV-positive pregnant women should be managed as per the Guidelines for the NHS Cervical Screening Programme 2010 [49]. Routine cytology should be deferred until after the delivery, but if follow-up cytology or colposcopy is advised because of a previously abnormal result, then this should be undertaken. GBA3 4.2.1 Newly diagnosed HIV-positive pregnant women do not require any additional baseline investigations compared with non-pregnant HIV-positive women other than those routinely performed in the general antenatal clinic. Grading: 1D 4.2.2 HIV resistance testing should be performed prior to initiation of treatment (as per BHIVA guidelines for the

treatment of HIV-1 positive adults with antiretroviral therapy 2012; www.bhiva.org/PublishedandApproved.aspx), except for late-presenting women. Post short-course treatment a further resistance test is recommended to ensure that mutations are not missed with reversion during the off-treatment period. Grading: 1D In the case of late-presenting women, cART, based on epidemiological assessment of resistance, should be initiated without delay and modified once the resistance test is available. 4.2.3 In women who either conceive on cART or who do not require cART for their own health there should be a minimum of one CD4 cell count at baseline and one at delivery. Grading: 2D 4.2.4 In women who commence cART in pregnancy a viral load should be performed 2–4 weeks after commencing cART, at least once every trimester, at 36 weeks and at delivery.