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“Objective-To determine the efficacy and safety of topical administration of selamectin and to compare selamectin treatment with a common ivermectin protocol for the treatment of natural infestation with Trixacarus caviae in pet guinea pigs.
Design-Clinical trial.
Animals-17 mixed-breed pet guinea pigs with active mite infestation.
Procedures-Guinea check details pigs were randomly allocated to receive a
single dose of selamectin topically (15 mg/kg [6.8 mg/lb]) or ivermectin (400 mu g/kg [181.8 mu g/lb], SC) every 10 days for 4 injections. Microscopic examination of skin scrapings from all animals was performed at 10-day intervals for 60 days, and the presence of mites or mite eggs was recorded. The efficacies of the 2 treatment protocols were compared at every time point.
Results-Pruritus resolved by day 10 in all animals. Animals were microscopically mite-free on days 30 and 40 in the selamectin and ivermectin treatment groups, respectively, but groups did not differ significantly in regard to the number of mite-positive animals at any timepoint.
Recurrence of infection was not noted in either treatment group. No adverse reactions were observed in any of the treated animals.
Conclusions and Clinical Relevance-Results suggested that a single topical application of selamectin at a dose of 15 mg/kg or repeated SC injection of ivermectin at a dose of 400 mu g/kg can eliminate T caviae mites from guinea pigs within 30 and 40 days, respectively. Although effectiveness did not significantly differ between RepSox supplier the 2 treatments, the convenience associated with the single topical dose of selamectin made it a preferable treatment modality for both patients and owners. (J Am Vet Med Assoc 2012;241:1056-1058)”
“Microphase separation behavior on the this website surfaces of poly(dimethylsiloxane)-block-poly(2,2,3,3,4,4,4-heptafluorobutyl methacrylate)
(PDMS-b-PHFBMA) diblock copolymer coatings was investigated. The PDMS-b-PHFBMA diblock copolymers were successfully synthesized via atom transfer radical polymerization (ATRP). The chemical structure of the copolymers was characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy. Surface composition was studied by X-ray photoelectron spectroscopy. Copolymer microstructure was investigated by atomic force microscopy. The microstructure observations show that well-organized phase-separated surfaces consist of hydrophobic domain from PDMS segments and more hydrophobic domain from PHFBMA segments in the copolymers. The increase in the PHFBMA content can strengthen the microphase separation behavior in the PDMS-b-PHFBMA diblock copolymers. And the increase in the annealing temperature can also strengthen the microphase separation behavior in the PDMS-b-PHFBMA diblock copolymers.