All patients with acute abdominal pain that was Hedgehog antagonist diagnosed as perforated peptic ulcer were enrolled in the study. A formal written consent was obtained on each case based on our institute ethical committee recommendations. Excluded from this study were those patients with concomitant bleeding from

the ulcer and evidence of gastric outlet obstructions. Patients with Boey risk score of 3 or more were excluded from laparoscopic interventions as they underwent a laprotomy approach. The Boey risk scoring system, propose by Boey et al. in 1987 [12], is well known for stratification of high risk patients in PPU. Also excluded were those with repeated upper abdominal operations, sever profound

shock, extreme age, bleeding tendency, or the RAD001 mw ulcer that was suspected to be malignant. The collected demographic data were age, gender, American Society of Anesthesiologists Association Score (ASA), presence of shock, White blood cell (WBC) count, Boey risk factor and co-morbidities of the patients. Major medical illness, preoperative shock, intra-operative findings such as the location and size of perforation, severity of abdominal cavity contamination were all reviewed. It was surgeon’s discretion to decide whether omental patch be added buy 7-Cl-O-Nec1 or not after the perforated ulcer was closed. Patients underwent the first aid supportive methods of not taking anything orally (NPO), the insertion of a naso-gastric tube for gastric decompression. Intravenous

fluids were initially administrated in the form of crystalloids (saline or ringer’s lactate solution). Intravenous antibiotics were given in the form of third generation cephalosporin’s as well as metronedazole. Routine laboratory tests were done including a complete blood counting (CBC) with differential leucocytes’ count; serum amylase and lipase were carried out to exclude acute pancreatitis. Moreover, all patients underwent abdominal x-rays to aid in diagnosing peritonitis. In cases where the X-rays were not conclusive; computed tomography (CT) was applied. Laparoscopy All procedures were Unoprostone performed by the same senior consultant surgeon. In brief, patient was placed in a 15–20_ reverse Trendelenburg position. The operating surgeon stands to the patient’s left side. The periumbilical region is the usual site for initial access; however, in 2 patients with previous midline incisions dictated the use of another “”virgin”" site. Carbon dioxide pneumo-peritoneum with the insufflations pressure of 14–15 mmHg was applied in most cases; yet, we have used lower levels (8–12 mmHg) due to concerns of hemodynamic compromise with higher pressures in those patients with delayed onset of symptoms.