73 +/- 0.68 mu mol/min (by a factor of 6.3) (p < 0.05) in SHR and WKY, respectively, thus confirming the presence of exaggerated natriuresis in SHR. FELi rose to 34 +/- 4 and 29 +/- 2 (p < 0.05) and C-Na/C-Li rose to 3.0 +/- 0.8 and 2.0 +/- 0.6 (p < 0.05) in SHR and WKY, respectively, demonstrating that Na reabsorption in both the proximal and the distal nephron was involved. Additional experiments showed that giving the rats saline instead of water to drink for four days prior to the clearance measurement led to a remarkable increase

in the natriuretic response to volume expansion. There was a close correlation between the peak increase in FENa and the logarithmic values of the baseline FENa values. In conclusion, the study confirms the LDK378 presence of an exaggerated natriuresis in response to volume expansion in conscious SHR rats compared to WKY rats, and that the renal response to acute volume expansion is related to the baseline sodium excretion.”
“Background. In the operating room and at the ICU, Rotational thromboelastometry (ROTEM (R)) and multiple platelet function analyzer (Multiplate (R)) Selisistat are frequently performed

on arterial blood samples while known reference ranges refer to venous blood only. To evaluate whether there are clinical important differences between parameters measured in arterial and venous blood, we performed a prospective study in patients undergoing orthopedic surgery. Methods. Arterial and venous blood samples were drawn simultaneously after line insertion (T0), intraoperatively (T1), at the end of surgery (T2) and the INTEM (R), EXTEM (R) and FIBTEM (R) ROTEM assays, as well as the ASPI (R), ADP (R) and TRAP (R) assays were performed in arterial and venous samples using the ROTEM (R) and the Multiplate (R) device, respectively. Results. After informed consent, 52 patients were enrolled and data of 50 patients remained for final analysis. Venous and arterial measurement results correlated significantly with a coefficient

of 0.519-0.977. At the three measurement points only a few statistically significant deviations were detected for some of the ROTEM (R) and Multiplate (R) parameters. The magnitude of differences was small and most likely without clinical relevance. PP2 price Pathological conditions were detected with similar frequency regardless of the sampling site. Only Multiplate (R) TRAP at T0 indicated low platelet aggregation more frequently in venous than in arterial samples (p = 0.0455); however, values were only narrow below reference range. Conclusion. The observed differences between arterial and venous results were within the range of variability of the methods reported for venous blood. Pathological values that might be clinically relevant could be detected at similar rates regardless of the sampling site.”
“Objective.