[3] may be sufficient in couples in whom

it is known to both partners that the HIV-infected individual has high compliance. Because of differences in demography and health care management, our results presumably cannot be applied to developing countries. Assuming that there is a viral threshold of infectiousness, our results indicate that the risk of viraemia is very low in patients on successful antiretroviral treatment. HIV-infected patients have, however, an increased risk of abrupt viraemia in not only the first 6 months but the first 12 months of episodes with undetectable VL. We thank the staff of our clinical departments for their continuous support and enthusiasm. Centres in the Danish HIV Cohort Study: Departments of Infectious Diseases at Copenhagen University Hospitals, Rigshospitalet (J. find more Gerstoft and N. Obel) and Hvidovre (G. Kronborg), Odense University Hospital (C. Pedersen), U0126 Aarhus University Hospitals, Skejby (C. S. Larsen) and Aalborg (G. Pedersen), Herning Hospital (A. L. Laursen), Helsingør Hospital (L. Nielsen) and Kolding Hospital (J. Jensen). Conflicts of interest NO has received research funding from Roche, Bristol-Myers Squibb, Merck Sharp & Dohme, GlaxoSmithKline, Abbott, Boehringer Ingelheim, Janssen-Cilag

and Swedish Orphan. FNE has received research funding from Merck Sharp & Dohme. JG has received research funding from Abbott, Roche, Bristol-Myers Squibb, Merck Sharp & Dohme, Pharmasia, GlaxoSmithKline, Swedish Orphan and Boehringer Ingelheim. LHO, MVL, LDR and TQ have no conflicts of interest. Financial support The study was

financed by The Research Foundation at Copenhagen University Hospital, Rigshospitalet and Faculty of Health Science, Copenhagen University. The fund providers had no role in the study design; in the collection, management, analysis or interpretation of data; in the preparation, review or approval of the manuscript; or in the decision to submit the article for publication. The researchers are independent of the fund providers. Financial disclosure The authors have no conflict of interest to report. “
“The PubMed database was searched under the following heading: HIV or AIDS and central nervous system infection or space-occupying lesion or meningitis Cediranib (AZD2171) or encephalitis or pneumonitis and/or Cryptococcus neoformans, cryptococcosis, Toxoplasma gondii, toxoplasmosis, progressive multifocal leukoencephalopathy, cytomegalovirus or CMV. Disease of the central nervous system (CNS) is common in HIV. It may be a direct consequence of HIV infection or an indirect result of CD4 cell depletion. Presentation may be predominantly manifested as a space-occupying lesion(s), encephalitis, meningitis, myelitis, spinal root disease or neuropathy (Table 2.1), and may occur in isolation or together with other HIV-related disease.