2). Signs of impaired arterial wall tone occurred as vascular bruits and heart tone registered not only in
dopplerograms of carotid arteries but also in intracranial arteries were found in 48 of cases. 16 patients had additional mid-diastolic wave as additional wall distention (not exceeded 0.02 ± 0.01 cm) accompanied by high systolic blood flow velocity with a prominent increase of systolic/diastolic velocities ratio. All these patients had significant brachial pressure fall during orthostatic test indicated the lack of autonomic nervous regulation (Fig. 3). The strong correlations exist between carotid arterial elastic properties and carotid Pembrolizumab clinical trial baroreceptors, cardiovagal baroreflex sensitivity with an impact on arterial blood pressure and stroke volume. We can assume the interdependency between carotid distensibility and autonomic balance. Whereas some studies suggest that reduced elastic properties of carotid arteries cause the reduction of cardiovagal baroreflex sensitivity resulted in changes of hemodynamic, the results of our previous and recent studies
show the dependence of carotid arterial distensibility on autonomic neural regulation of wall tone. The autonomic imbalance in young people was associated with the increase of arterial distensibility, expressed as increase of carotid arterial systolic/diastolic diameter change, sometimes additional arterial mid-diastolic wall motion, accompanied by abnormal distribution of flow http://www.selleckchem.com/B-Raf.html velocity
during cardiac cycle with the marked systolic flow acceleration and significant increase of systolic/diastolic ratio. This conclusion coincides with the findings of the decreased arterial stiffness in a young people under the acute sympathetic stimulation of artery. These results may be explained by an unloading of stiffer wall components during active arterial constriction under influence of autonomic stimulation [27]. The further comparable evaluation of patients with different impairment of nervous system could help to determine the role of nervous regulative function on Anacetrapib arterial wall dynamics. Taking into account many basic mechanisms and various factors influencing arterial wall dynamics it is difficult to measure the impact of each of them separately. Arterial wall stiffness or distensibility measurements reflect the dynamics of all structures of the arterial wall as well as dynamics of blood perfusion. Arterial mechanical properties can be calculated in different ways including parameters of various factors affecting wall motion. The development of the high resolution ultrasound tracking techniques makes it possible more accurate measurements of arterial elastic properties which is extremely important for early detection of vascular pathology. “
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