57% (42-86), P = 0.03], but substantial salvage (> 50% of AAR) was observed in 41% of late presenters despite total infarct-artery occlusion.\n\nFIS is larger in late presenters (> 12 h) than early presenters after primary angioplasty for STEMI. However, substantial

myocardial salvage can be FK866 obtained beyond the 12 h limit, even when the infarct-related artery is totally occluded.”
“Late presentation of HIV is common and is associated with several adverse outcomes including an increased risk of clinical progression, blunted immune recovery on highly active antiretroviral therapy and a greater risk of drug toxicity. Late presenters may have higher rates of poor adherence, exacerbated by the same factors that contribute to their late diagnosis, such as lack of knowledge about HIV and the benefits of highly active antiretroviral therapy. We review the definitions of, risk factors for Ilomastat and subsequent impact of late presentation. Evidence regarding how and when to start antiretroviral therapy,

and with which agents, will be discussed, as well as issues surrounding vaccination and opportunistic infection prophylaxis for individuals with a low CD4 count. Finally, strategies to increase HIV testing uptake to reduce late presentation will be summarized.”
“PURPOSE To evaluate visual performance and aberrations with aspheric and spherically neutral microincision intraocular lenses (IOLs) and assess the influence of asphericity on visual performance, wavefront aberration, and depth of focus.\n\nSETTING: St. Thomas’ Hospital, London, United Kingdom.\n\nDESIGN: Clinical trial and cohort study.\n\nMETHODS: In

the first study, patients with bilateral cataract were randomized to receive an aspheric Acri.Smart 36A IOL or a spherically neutral Akreos MI60 IOL in the first eye. The other IOL was implanted see more in the second eye within 3 weeks. Assessments at 3 months were 100% and 9% corrected distance visual acuity (CDVA) and distance-corrected near visual acuity (DCNVA). Aberrations and depth of locus were computed using iTrace software. In the second study, data from the other published study was combined to assess the visual performance, aberration, and depth of focus in groups of spherical, spherically neutral, and negatively aspheric (asphericity -0.17 mu m) IOLs.\n\nRESULTS: In part 1, there was no difference in 100% or 9% CDVA, DCNVA, or depth of focus between the 2 microincision IOLs. Total spherical aberration was lower with the aspheric IOL. In part 2, the CDVA and DCNVA were not different between the spherical (n = 44), spherically neutral (n = 32), or aspheric (n = 76) IOLs. Total spherical (P<.01) and vertical coma aberrations decreased with increasing IOL asphericity (P<.01). Depth of focus (4.0 mm pupil) also decreased with increasing asphericity and was significant between the spherical IOL and aspheric IOLs. The DCNVA did not differ between groups.